解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Pneumocystis carinii pneumonia (PCP) is the most common illness associated with the acquired immunodeficiency syndrome (AIDS) in the United States and also occurs in immunocompromised persons not infected with the human immunodeficiency virus.. Several advances have taken place in the treatment and prophylaxis of PCP,...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1997-09-01 00:00:00
abstract::We compared total costs and adherence to the regimen of older versus newer angiotensin-converting enzyme (ACE) inhibitors for the treatment of elderly patients with hypertension. A computer search using the data base of a health care insurer identified 6176 subjects age 65 years or older who had ICD-9 coding for hyper...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::A prospective cohort study was conducted in 35 hospitals with oncology units to determine the incidence of symptomatic cardiotoxicity in patients receiving continuous infusions of 5-fluorouracil (5-FU), and to identify risk factors that could contribute to the development of 5-FU-associated cardiotoxicity. A sample of...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1997-07-01 00:00:00
abstract::A pharmacist consult service was developed to evaluate the appropriateness of enteral feeding through a permanent ostomy in 24 nonambulatory patients with severe developmental disabilities. Several problems with enteral nutrition were identified. Policies to improve them were instituted, and several educational presen...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract:STUDY OBJECTIVE:To characterize a time-dependent disposition of oral tacrolimus and its relationship with plasma endothelin-1 concentrations. DESIGN:Randomized, crossover study. SETTING:Clinical research center of a university-affiliated hospital. PATIENTS:Twelve stable liver transplant recipients. INTERVENTIONS:In...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1997-05-01 00:00:00
abstract::To determine salary and selected fringe benefits of members of the Ambulatory Care Practice and Research Network of the American College of Clinical Pharmacy, we developed a self-administered questionnaire that surveyed demographic information, schooling and training, academic appointments, yearly salary (as of Februa...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract::Torsades de pointes is a polymorphic ventricular tachycardia characterized by marked QT prolongation on the electrocardiogram. It can be induced by both antiarrhythmic and nonantiarrhythmic drugs, such as quinidine and erythromycin. No extensive literature documents an interaction between quinidine and erythromycin wh...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract::Panic disorder is a frequently chronic condition with extensive patterns of psychiatric comorbidity. Optimum pharmacotherapy with traditional agents is limited by side effects, long-term tolerability, and other problems. Recent research findings support the characterization of panic disorder as an illness involving de...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Our patient experienced acute renal failure but not fulminant hepatic failure from acetaminophen toxicity. OBJECTIVE:To review the clinical and laboratory characteristics of similar cases of acetaminophen nephrotoxicity. METHODS:A MEDLINE search and medical record search at two large teaching hospitals. R...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the efficacy and safety of a new combination product, enalapril-diltiazem ER, when administered over the long term. DESIGN:Open-label, titration to response, with treatment lasting 46 weeks after a 6-week, double-blind phase. SETTING:Medical clinics in the private and academic sectors. PA...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1997-01-01 00:00:00
abstract::A 43-year-old man with a 19-year history of Crohn's disease experienced serum sickness with acute lobular panniculitis and vasculitis within 2 weeks of initiating 6-mercaptopurine therapy. He had no history of extraintestinal manifestations of Crohn's disease or drug allergy. Symptoms included disabling joint pain, pr...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Original research, reviews, and case reports discussing viral infectivity of blood- and plasma-derived products were reviewed to determine the potential viral infectivity of human serum albumin (HSA) and plasma protein fraction (PPF). Data concerning viral infectivity viral screening and inactivation procedures, and v...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1996-11-01 00:00:00
abstract::Nausea and vomiting are common complaints in the postoperative period and contribute to patient distress and delay of discharge for outpatient surgical procedures. Laparoscopic procedures are associated with a high incidence of postoperative nausea and vomiting (PONV) episodes. Parenteral use of metoclopramide prevent...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-11-01 00:00:00
abstract::Warfarin is a commonly used oral anticoagulant that is usually initiated after the definitive diagnosis of a certain thromboembolic disorder or disease. Warfarin therapy will usually be prescribed for 6-12 weeks or more, and some patients may continue therapy throughout life, depending on the type of thromboembolic di...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract::The atypical antipsychotic agents clozapine and risperidone bring new insight into the care and treatment of patients with schizophrenia. Since their introduction, several names (e.g., novel, atypical, serotonergic-dopaminergic antagonist) have been used to describe the nature of these compounds. The agents are unique...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1996-11-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the activity of CYP2D6, N-acetylation, and xanthine oxidase, three drug-metabolizing enzyme systems, in patients with cystic fibrosis and compare the findings with those in individuals without the disease. DESIGN:Prospective cohort study. SETTING:General pediatrics service. PATIENTS:Fift...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::Verapamil and diltiazem are effective in terminating paroxysmal supraventricular tachycardias and slowing ventricular response during atrial fibrillation or flutter. Results from clinical trials for each individual drug demonstrate comparative efficacy rates, and both drugs share the same contraindications and relativ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1996-09-01 00:00:00
abstract::Data obtained from 23 critically ill patients treated with intravenous ciprofloxacin in two clinical trials were used to validate prospectively a previously developed maximum a posteriori (MAP)-Bayesian estimator and optimal plasma-sampling strategy (OSS). Dosages ranged from 200 mg every 12 hours to 400 mg every 8 ho...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::Clinical trials continue to evaluate the pharmacologic management of myocardial infarction for benefits in mortality, degree of infarct artery patency, and frequency of reocclusion. The discovery of thrombus formation in the development of the myocardial infarction renewed interest in thrombolytic therapy. In appropri...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1996-09-01 00:00:00
abstract::The Internet is an excellent source of drug and poison information. Despite the relative case and minimal costs associated with accessing the Internet, many pharmacists and other health care professionals have been slow to adopt this new technology. ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the safety, tolerability, and pharmacokinetic profile of fosphenytoin, a water-soluble phenytoin prodrug, after intramuscular and intravenous administration. DESIGN:Open-label study of intramuscular administration, and double-blind, randomized study of intravenous administration. SETTING:S...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1996-07-01 00:00:00
abstract::A 69-year-old woman was admitted for control of intractable rectal pain caused by a 4-cm malignant mass. She was treated successfully with EMLA (eutectic mixture of local anesthetics) cream applied every 8 hours and covered with a Xeroform dressing. Despite an increase in tumor size to 6 cm, her pain control was maint...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract::Peripheral blood has replaced bone marrow as a source of hematopoietic stem cells for autologous rescue after high-dose chemotherapy. Patients who receive peripheral blood stem cell (PBSC) transplants experience rapid and sustained hematopoietic reconstitution. As a result, transplant-related mortality is now less tha...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract:STUDY OBJECTIVES:To determine if low-dose lovastatin in combination with niacin causes a greater percentage reduction in low-density lipoprotein (LDL) cholesterol than lovastatin alone, and to determine if the combination increases the risk of serious adverse effects. design. Prospective, randomized, open-label, clinic...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-05-01 00:00:00
abstract::We retrospectively reviewed the charts of 120 patients who received an initial prescription of iron from a resident physician in internal medicine to determine how accurately house officers diagnose iron-deficiency anemia before initiating iron therapy. Each patient's laboratory records were reviewed for the 3-month p...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract::We reviewed the spectrum of activity, pharmacokinetics, clinical efficacy, adverse effects, and relative advantages of piperacillin-tazobactam, a new beta-lactam-beta-lactamase inhibitor. Piperacillin-tazobactam has a wide spectrum of activity that includes gram-positive organisms such as staphylococci and streptococc...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract::Bar code technology has been used for 5 years to improve the efficiency of identifying and documenting clinical pharmacy services at our institution. Data for an entire year (1993) were analyzed to quantify the nature and magnitude of pharmacy services provided for critically ill patients in intensive care units (ICU)...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract::Cisplatin in combination with other cytotoxic agents is the backbone for a potential cure of testicular germ cell neoplasms and is a critical factor in the substantial activity observed in the treatment of small cell lung cancer, bladder cancer, and ovarian germ cell tumors. Resistance to cisplatin at the onset of tre...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
abstract::The primary objective of this study was to determine if a pharmacist-managed anticoagulation monitoring service (AMS) improved the outcomes of patients receiving warfarin in a family practice setting and was cost effective in treating and preventing thromboembolic disorders. A retrospective chart review was performed ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract::We cared for a patient in whom iron dextran administration interfered with the determination of total serum calcium concentration. An unexpected elevation in serum phosphorus concentration also occurred after the iron dextran infusion. A MEDLINE search from 1966 to present was conducted, and the manufacturer of the ir...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract::Several worldwide initiatives involve pharmacy education and practice; however, the International Pharmaceutical Federation is the only worldwide pharmacy organization currently in existence. This is the first report of the good pharmacy practice initiative published in the United States. We hope that it will stimulat...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/j.1875-9114.1995.tb02867.x
更新日期:1995-09-01 00:00:00
abstract::A 40-month-old child was sedated with a fentanyl and midazolam infusion for 7 days. After the drugs were discontinued he became unresponsive and globally aphasic, and had marked thrombocytosis. He was hospitalized for 4 weeks, during which time his motor and cognitive status slowly improved, and had almost returned to...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/j.1875-9114.1995.tb02877.x
更新日期:1995-09-01 00:00:00
abstract::Human herpesvirus infections continue to be a concern in immunocompetent as well as immunocompromised hosts. They are often life threatening in the immunocompromised patient. In the healthy immunocompetent person the infections tend to be self-limited, although they can directly or indirectly cause periods of severe d...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1995-09-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the appropriate compartmental and noncompartmental pharmacokinetic parameters for intravenous piperacillin and tazobactam. DESIGN:Sequential selection of patients entered into a randomized, open-label clinical efficacy trial. SETTING:Los Angeles County-University of Southern California Me...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-07-01 00:00:00
abstract::A previously healthy 25-year-old man with metastatic testicular teratocarcinoma became resistant to atracurium-induced neuromuscular blockade as evidenced by train-of-four (TOF) monitoring combined with clinical assessment. Subsequently he had an adequate response with a standard dosage of pancuronium. During the firs...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract::This study documents a pharmacokinetic interaction between carbamazepine and cyclosporine (CsA) in pediatric renal transplant recipients. Noncompartmental steady-state CsA pharmacokinetics were determined in three pediatric renal transplant recipients who were receiving both CsA and carbamazepine as long-term therapy ...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract:STUDY OBJECTIVES:To determine whether glomerular filtration rate (GFR) changes during induction chemotherapy in children with leukemia, and to examine GFR as a determinant of pharmacokinetic variability of methotrexate clearance. DESIGN:Prospective, unblinded observational study in consecutive patients. SETTING:A res...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::A major factor in delivering patient care is documenting activities by pharmacists. This documentation is not only essential to sustain existing programs but necessary to justify future growth of resources. A computerized documentation system for clinical interventions and workload activities was developed in a 340-be...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::High-performance capillary electrophoresis (HPCE) is a new separation technique that is applied in the pharmaceutical sciences. Separations by HPCE occur in a narrow-bore capillary under the influence of an applied electrical field. Components of the sample matrix are separated and migrate at different rates based on ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract::We attempted to determine if an association exists between vancomycin serum concentrations resulting from traditional dosing regimens, and efficacy and toxicity outcomes. We reviewed the medical charts of 273 consecutive patients prescribed 273 courses of vancomycin therapy for documented, gram-positive bacteremia. Of...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00